autoimmunediseases相关论文
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1例48岁女性接种四价流感病毒裂解疫苗，7 d后甲状腺左侧出现压痛及触痛性包块，诊断为亚急性甲状腺炎。予塞来昔布胶囊200 mg口服、2......
Chimeric antigen receptor T cells(CAR-T cells)are engineered recombinant T cells,which were initially used to treat hema......
糖基化修饰是免疫球蛋白G（IgG）结构和功能的一部分，唾液酸位于IgG N-糖链的最末端，通过调节IgG与可结晶片段γ受体及补体的结合而调控I......
Autoimmune diseases with hematological manifestations are often characterized by chronicity and relapses despite treatme......
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环状RNA(circRNAs)是一种无3\'聚腺苷化[poly-(A)]尾或5\'帽的共价闭合环结构非编码RNA(ncRNA),是一个崭新的研究领域.环状RNA......
Autoimmune diseases are chronic immune diseases characterized by dysregulation of immune system,which ultimately results......
OBJECTIVE:To investigate the therapeutic effect of Er-Xian decoction (二仙汤,EXD) on the autoim-mune premature ovarian f......
Mycophenolic acid synergizes with lipopolysaccharide to induce interleukin (IL)-1 release via activa
Background: Mycophenolate mofetil (MMF), which inhibits T and B lymphocyte proliferation, is widely used to treat a vari......
Protein Flexibility in Docking-based Virtual Screening:Discovery of Novel Lymphoid-specific Tyrosine
Incorporating protein flexibility is a major challenge for docking-based virtual screening[1].With an increasing number ......
Lymphocyte transformation from autoimmune haematological diseases to lymphoproliferative syndrome an
Autoimmune diseases (ADs) have close relationship with the onset of malignant lymphoma.The recent research focuses on AD......
Identification of Novel Lymphoid Tyrosine Phosphatase Inhibitors Using Pharmacophore-based and Docki
The lymphoid tyrosine phosphatase LYP,encoded by the PTPN22 gene,is a critical regulator of signaling in T cells.A singl......
Im58, a new toxin from the Scorpion Isometrus maculates venom, potently and selectively blocks Kv1.3
Kv1.3 channels have become a novel target for the treatment of autoimmune diseases.Searching for specific Kv1.3 potassiu......
Structural basis of a potent peptide inhibitor designed for Kv1.3 channel,a therapeutic target of au
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The comparison of BLyS-binding peptides from phage display library and computer-aided design on BLyS
BLyS antagonists have become the therapeutic reagents in the treatment of autoimmune disorders.BLyS binding peptides and......
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Mycophenolic Acid Synergizing with Lipopolysaccharide to Induce Interleukin-1β Release via Activatio
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Monoclonal B-cell Lymphocytosis in a Patient with Wegener Granulomatosis: A Case Report and Update o
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自身免疫性疾病近年发病率逐渐增长。近来研究表明，γδT细胞在免疫反应早期阶段通过分泌炎性细胞因子和趋化因子等来诱导自身免疫......
MicroRNAs(miRNAs)are short non-coding RNAs that play an important role in posttranscriptional regulation of gene exp......
目的研究抗核抗体谱检测对自身免疫性疾病诊断价值。方法选取2018年9月至2019年9月在某院接受抗核抗体谱检测的100例自身免疫性疾......
糖基化是蛋白质生物合成过程中最重要的翻译后修饰之一，免疫球蛋白糖基化可通过调节抗体稳定性和影响其与不同FcγRs的相互作用，发挥......
目的采用基于组织底物实验及实验室内部基于细胞底物实验的抗代谢型谷氨酸受体1抗体联合检测方法，对既往病因不明的1例以小脑性共济......
糖皮质激素冲击治疗是神经系统免疫性疾病急性期诱导缓解的重要手段。但目前国内各医院激素冲击治疗的具体方案并不规范和统一，与国......
多种抗原参与自身免疫性葡萄膜炎的发生发展,但是这些抗原的免疫优势表位尚不明确.针对视网膜S抗原等葡萄膜炎自身抗原免疫表位的......
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Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system.Although the exact underlying m......
补体系统作为机体固有免疫系统的一部分，在吞噬异源物、清除免疫复合物和凋亡细胞以及参与获得性免疫等方面起着重要的作用。补体系......
Elevated Levels of Serum IgA against Saccharomyces cerevisiae Mannan in Patients with Rheumatoid Art
This study was undertaken to investigate whether levels of anti-Saccharomyces cerevisiae mannan antibodies (ASCMA) in hu......
自身免疫性疾病是机体对自身抗原的免疫耐受机制破坏，导致一个或多个器官的免疫性损伤。目前，大多数自身免疫性疾病的治疗策略仍是长......
自噬是真核细胞的Ⅱ型程序性细胞死亡过程，自噬失调会导致多种疾病的发生。该领域已经成为目前生物医学研究的热点，而通过调控自噬活......
白细胞介素10（IL-10）是机体的重要免疫调节因子，主要由辅助性 T细胞（Th）2分泌，它能广泛抑制Th1细胞因子的合成与分泌，并参与多种细胞生物......
雷公藤多苷是从雷公藤根提取并精制而成的一种脂溶性混合物，具有抗炎、活血化瘀、清热解毒、免疫等功能，也是临床应用广泛的治疗类风......
目的 探讨血清维生素D与自身免疫性甲状腺疾病之间的相关性.方法 共筛选520例健康体检者,检测血钙、血磷、甲状旁腺激素(PTH)、甲......
目的 对比分析自身免疫性胰腺炎(AIP)患者与胰腺癌(PC)患者的影像学资料,提高AIP与PC在影像学方面的鉴别诊断能力.方法 选取术后病......
AIM: To investigate the role of soluble Fas ligand in autoimmune diseases.METHODS: RT-PCR was performed to amplify sFasL......
目的 探讨18 F-FDG PET/CT全身显像在自身免疫性胰腺炎(AIP)诊断及全身评估中的价值.方法 回顾性分析2010年8月至2013年2月长海医......
目的分析自身免疫性胰腺炎(AIP)胰腺及其他组织器官受累的影像学征象，以提高AIP影像学诊断及鉴别诊断水平。方法回顾性分析2011年至......
目的分析IgG4相关胆胰疾病患者的临床特征，提高对此类疾病的认识。方法回顾性分析9例IgG4相关胰腺炎及胆管炎患者的临床表现，血清学......
目的 检测慢性胰腺炎(CP)患者各项血液自身免疫指标的阳性率,探讨其临床价值.方法 检测上海长海医院消化科就诊的409例CP患者的抗......
Background: Rheumatoid arthritis is a kind of chronic systemic autoimmune diseases that invade mainly in articulation. I......
IL-10是一种被广泛表达的单链糖蛋白多效细胞因子,既可以由适应性免疫细胞产生也可以由固有免疫细胞产生.IL-10的特异性受体是复合......
Nonmyeloablative conditioning regimens are the logical and safer approach for both autologous and allogeneic hematopoiet......
Traditional Chinese medicine is a useful and promising alternative strategy for treatment of Sjogren
Primary Sjogren’s syndrome(p SS)is a chronic autoimmune disease involving exocrine glands.Current studies have found th......
